You can connect to Blast by instantiating a new web3.js Web3 object with a RPC URL of the Blast network.

Mainnet

const { Web3 } = require('web3');

const web3 = new Web3('https://rpc.blast.io');

See Network Information for additional mainnet RPC endpoints.

Testnet

const { Web3 } = require('web3');

const web3 = new Web3('https://sepolia.blast.io');